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Liquid Chromatography Evaporative Light Scattering Detector (HPLC-ELSD)
The ELSD detector analyzes any compound that is less volatile than the mobile phase. It can detect organic substances without UV absorption. The eluate is nebulized to form an aerosol, and the solvent is evaporated in a heated drift tube, leaving the remaining nonvolatile solute particles. Detection is obtained in a light scattering detection cell. Applied to lipids, underivatized fatty acids and amino acids, polymers, surfactants, etc.